Strategy for large intestinal mucosa targeting by suppositories dispersing microcapsules contained 5-aminosalicylic acid.
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چکیده
منابع مشابه
Electrochemical Synthesis of 5-Aminosalicylic Acid from 5- Nitrosalicylic Acid in Alkaline Media
5-Aminosalicylic acid (5-ASA) is currently prepared by electrochemical reduction of 5-nitrosalicylic acid (5-NSA) in acidic media. In this work, electrolytic reduction of 5-NSA in alkaline media is presented. Reactionconditions and parameters such as anode and cathode electrodes, electrolyte type, reaction time, temperature,current, and the pH for isolation of product are investigated. The yiel...
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5-Aminosalicylic acid given to rats as a single intravenous injection led to necrosis of the proximal convoluted tubules and of the renal papilla. These two lesions developed at the same time and the cortical lesions did not appear to be a consequence of the renal papillary necrosis. Since the compound possesses the molecular structure both of a phenacetin derivative and of a salicylate these o...
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BACKGROUND Treatment of ulcerative colitis or Crohn's disease with sulphasalazine causes several adverse effects, including hepatitis. Sulphasalazine is cleaved by colonic bacteria into 5-aminosalicylic acid and sulphapyridine. Received wisdom was that 5-aminosalicylic acid was topically active, whereas sulphapyridine was absorbed and caused immunoallergic side effects. Mesalazine, a slow relea...
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Simulation microcapsules reinforced by carbon nanotubes contained in a capsule-based self-healing materials
از آن جهت که مواد کامپوزیتی به خصوص کامپوزیتها با زمینه پلیمری ساختارهای آسیبپذیری نسبت به صدمات ایجاد شده در فرم ترک و شکستگی هستند. در سالهای اخیر تلاشهای علمی جدید در جهت ایجاد یک واحد کنترل داخلی صورت گرفته است، تا بتواند به صورت خودمختار در ترمیم کامپوزیتها عمل کند. نام این نظریه خودترمیمی است. نظریه خودترمیمی ناشی از همسانسازی بیولوژییکی، نشان میدهد؛ همانگونه که عمیقترین زخمها و...
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ژورنال
عنوان ژورنال: Drug Delivery System
سال: 1992
ISSN: 1881-2732,0913-5006
DOI: 10.2745/dds.7.57